WHO Classification of Tumours of the Central Nervous System

WHO Classification of Tumours of the Central Nervous System Books

Product Description
WHO Classification of Tumours of the Central Nervous System is the first volume of the 4th Edition of the World Health Organization run on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an obligatory guide for use in the design of studies monitoring response to therapy and clinical outcome.

Diagnostic criteria pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors.

This book is in the run commonly referred to as the “Blue Book” run.

The book prepared by 73 authors from 19 countries contains more than 400 color photographs, numerous X-rays, computed tomography (CT), magnetic resonance (MR) images, charts and more than 2,500 references.

…The title of this book is typically modest. It is not only a classification of tumours of the central nervous system but an authoritative and explicit account of this group of tumours…This the fourth edition contains a number of distinct improvements on previous editions both in layout and content… One new feature is the clear account of the WHO’s grading system its rationale and its application… New tumour entities are included…Newly recognized histological variants include pilomyxoid astrocytoma. Both anaplastic medulloblastoma and medulloblastoma with extensive nodularity have gained recognition in the classification… There are some differences in classification from the third edition most notably relating to anaplastic oligoastrocytoma. The exchange in emphasis follows cited differences in prognosis between mixed tumours with and without necrosis. Other changes are also apparent e.g. within the atypical teratoid/rhabdoid section mention of the INI-1 locus in the genetics section in the third edition has been expanded to include immunohistochemistry in the fourth edition. The fourth edition is unique in its clear-targeted and succinct style of presentation of tumors of the CNS… it will be of universal fascinate in neuro-oncology and will most certainly form the main basis for diagnosis by multidisciplinary teams administration patients with tumors of the CNS.”