The Organic Chemistry of Drug Design and Drug Action
The Organic Chemistry of Drug Design and Drug Action Books
Product Description
This is a new approach to the teaching of medicinal chemistry. The knowledge of the corporal organic chemical basis of drug design and drug action allows the reader to extrapolate to the many correlated classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!
* Emphasizes the use of the principles of corporal organic chemistry as a basis for drug design
* Discusses organic reaction mechanisms of clinically vital drugs with mechanistic schemes
* Uses figures and literature references extensively throughout
* This text is not merely a “compilation of drugs and uses,” but features selected drugs as examples of the organic chemical basis for any and all drug design applications
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The book was groundbreaking new just like it said in the description and it was shipped very quick.
Rating: 5 / 5
The book is fantastic for understanding the title theme. But it has too many references which distracts the reader. Also, many times, the corresponding picture of a particular topic covered is not in the same page as the topic. This requires going back and forth between pages. The problems at the end of each chapter are really excellent and checks the understanding of the theme painstakingly.
Rating: 4 / 5
This book is fantastic and covers a broad range of topics that fall into the category of rational drug design. The book goes in depth into topics dealing with each vital aspect of how drugs are exposed and bespoke to yield better drugs: from effects of chirality to electronic effects. The structure of drugs, at the molecular level are covered in detail, shiny every major aspect of drug structure. Then, interaction between drug (ligand) and enzyme, at the molecular level are covered.
In my estimation, to benefit most from this book, the reader should have a working knowledge of organic chemistry and biochemistry (at least protein secondary and tertiary structure).
Rating: 4 / 5
There is a new considerably expanded and updated edition available of Silverman’s already classic text as of Jan/04. ISBN is 0-12-643732-7. Check it out… price is comparable to the earlier edition.
Rating: 5 / 5
Some books of this nature tend to focus on the synthesis of drug molecules and less about how they work and why. This book is just the opposite and walks the reader through a logical progression of drug discovery, design and target specificity. This book makes a fantastic introduction to Goodman & Gilman’s The Pharmacological Basis of Therapeutics which may possibly be considered the bible of the theme.
Rating: 5 / 5