Protein Crystallography in Drug Discovery
Protein Crystallography in Drug Discovery Books
Product Description
The rational, structure-based approach has become standard in bestow-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are nearly exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.
Here, researchers from leading pharmaceutical companies bestow valuable first-hand in rank, much of it published for the first time. They discuss strategies to derive high-resolution structures for such vital target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A unique section on recent matter-of-fact developments, such as for high-throughput crystallography and microcrystallization, is also included.
A valuable companion for crystallographers caught up in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
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