Prions: The New Biology of Proteins
Prions: The New Biology of Proteins Books
Product Description
Prion-correlated diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease — transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy –brought prion-correlated diseases international attention. Exceptionally dramatic, these diseases progressively and inexorably ruin the cognitive, motor, and sensorial skills that are the essence of human beings.
Prions: The New Biology of Proteins provides a well-organized overview of what is known about prion-correlated diseases. This comprehensive work reviews the symptoms, epidemiology, and neuropathology of the disease. It focuses on evidence supporting the thought that TSEs result from a novel disease means: transmission by replication of the misfolding of a single protein in the absence of nucleic acids. Following this hypothesis, the book examines the structure, conversion, and means of prion propagation and details its cellular biology. It explores the transmission, discusses the challenges caught up with diagnosis, and considers various therapeutic avenues that are presently being explored.
A cohesive volume that integrates the revolutionary work of many researchers, this book is authored by Claudio Soto, an internationally celebrated researcher whose innovative work has led to an increased understanding of the heretical biology of prions and the development of novel strategies for treating and diagnosing neurodegenerative diseases.
As protein misfolding diseases are his specialty, Soto also looks at the phenomenon from a wider perspective. He examines other diseases that show folding aberrations, considers how commonly such aberrations occur in nature, and questions readers to open their minds to consider the impact of prions on broader areas of biology, broadcast health, and biotechnological strategies.
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