Pheochromocytoma, Annals of the New York Academy of Sciences, Volume 1073: First International Symposium
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Pheochromocytoma is a rare neuroendocrine tumor with a highly variable presentation. There is lack of agreement about the most well-organized and cost-effective methods for diagnosis and localization of the tumor, which can be lethal if not identified and treated promptly.Autopsy studies indicate that up to 50% of all cases remain undiagnosed until death.
Between 30 and 35% of the tumors have a hereditary basis. Development of malignancy is highly variable — from less than 5% to more than 50% depending on the mutation; there is now no effective cure.
This volume encompasses a number of themes in several sections: genetics and clinical choice-making; genetics, molecular pathways of tumorigenesis, and different phenotypes; kaleidoscopic presentations and a minefield for differential diagnosis of pheochromocytoma; biochemical diagnosis: can we reach consensus?; tumor localization and the evolving importance of functional imaging; and new molecular markers and targets for diagnosis and treatment of malignant pheochromcytoma.
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