One Renegade Cell: The Quest For The Origin Of Cancer
One Renegade Cell: The Quest For The Origin Of Cancer Books
Product Description
For everyone whose life has been touched by cancer, One Renegade Cell tells the tale of the search for the ultimate causes of this dreaded disease.
“One Renegade Cell…offers a breathtaking picture, both wonderful and frightening, of the fantastic intricacy of peculiar cellular functioning.” -New York Times
“Part primer, part history and part meditation. [One Renegade Cell] succeeds on all counts.” -Wall Street Journal
One of the leading cancer researchers in the world, Robert A. Weinberg is perfectly suited to describe the search for cancer’s origins from the early days of this century to the bestow. Presuming small knowledge of biology, he tells how a cancer-causing virus was first exposed in 1909, how the correlation was made between chemical carcinogens and cancer, and how oncogenes (the genes that can turn a cell malignant) work. He clarifies clearly how malignant cells send messages to one another and also block the messages of normal cells. Finally, Weinberg predicts that cancer prevention may depend on our ability to know the mysterious chemical clock that regulates our cells’ most basic functions. One Renegade Cell offers a concise, accessible route into the complex and often daunting world of cancer and cancer research.Amazon.com Review
“Cancer wreaks havoc in nearly every part of the human body”–Robert Weinberg’s opening remark is a alarming reminder of the pervasiveness of an all-too-familiar disease. Cancer touches most families, and if you have ever wondered why, despite so much time, effort, and money, it has proved such a seemingly intractable problem, then read One Renegade Cell, Robert Weinberg’s masterful explanation. As director of the Oncology Research Laboratory at the Whitehead Institute and professor of Biology at MIT, Weinberg has been at the forefront of cancer research for well over a decade.
Unlike most diseases, cancerous tumors are not foreign invaders but “take on the appearance of alien life forms, invaders that enter the body through stealth and start their programs of destruction from within.” But as Weinberg shows, these are unrepresentative appearances. And since he is foremost a scientist, he finds the truth “subtle and endlessly fascinating” and manages to convey fascination for something that most of us dread–cancer. Much of the bestow increase in cancer is due to increased longevity because “given enough time, cancer will strike every human body.”
By telling the tale of the historical discovery of cancer, Weinberg is able to initiate gradually the intricacies and complications of the genes and proteins caught up (oncogenes, tumor suppressor genes, etc.) for the general reader. He characterizes cancer cells as renegade because, unlike normal body cells, they “disregard the needs of the community of cells,” they are “selfish and unfriendly,” and are only interested in “their own proliferative advantage.” By comparison, normal cells hold down cell numbers by “inducing them to commit suicide” (apoptosis).
The understanding of cancer has been developed enormously over the last few decades by Weinberg and the worldwide community of researchers. As Weinberg pathetically shows, cancer research and its correlated disciplines “have went from substantial ignorance to deep insight.” –Douglas Palmer, Amazon.co.uk
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Extremely informative, written in fascinating form like a scientific novel, a systematic mini-survey of the molecular biology of cancer. Takes you through 30 years of discovery, explaining how fake expectations were replaced by the discovery in laboratories of aptly pathways. Among the helpful pieces of in rank you’ll pick up: cancer cells are not ruined by chemo and radiation, only some DNA hurt occurs. Unless the p53 gene is small enough hurt, then the tumor is not stopped, and Weinberg clarifies why. He fully describes the 6 mutations that are required, over time, to yield a metastasizing tumor. My wish: that Weinberg would next write a book about cancer treatments.
I end with an aside for those who are in like with the red herring called “holism”, and presume that “reductionism” is dead and of small or no use in the elucidation of complexity. The entire field of genetic and cancer discoveries, all of microbiology, is nothing but plain ol’ reductionism applied to very long molecules, molecules so long and often disordered in shape that new techniques of chemical analysis had to be invented (like PCR). This book and any standard text on molecular biology provides full evidence for the truth of my assertion.
Rating: 5 / 5
This book was not compulsory to me by a colleague. We worked in monoclonal antibody manufacturing and development, so I knew a thing or two about treatment of cancer, but I knew nothing about the disease itself. It’s an simple read (I read a lot of this book on the bike at the gym), it’s not dull at all, and it’s written clearly enough so that people with no biology knowledge at all can know it, but that it’s still very fascinating and informative to people that already have a science or engineering background. I would also highly urge reading Robert Weinberg’s paper in Cell from 2000 titled The Hallmarks of Cancer. It’s a fantastic supplement.
Rating: 5 / 5
This is an amzaing manuscript. By leading the reader through the key discoveries in modern molecular oncology , Weinberg is able to elucidate the hallmarks of carginogenesis in simple, yet comprehensive ways.
This is a must read for any doctoral student. But, Weinberg simple and entertaining language will be loved by anyone who has an interest in the pathways that lead to cancer.
Rating: 5 / 5
this is a fantastic book for people who know nothing about cancer and want to know. I had a opportunity to meet the author after he gave a address about his research and it was really awesome!
Rating: 5 / 5
This is a phenomenal book. It is fascinating and well written. I would urge it to anyone, including non-scientifically minded readers. If there were ten stars I would have given them.
Rating: 5 / 5