Fundamentals of Genetic Epidemiology
Fundamentals of Genetic Epidemiology Books
Product Description
With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including populace and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in defensive medicine, broadcast health scrutiny, and the emerging ethical issues regarding use of genetic in rank in society.
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There are some helpful nuggets for graduatre students, but this is a very trying book to use as a primary textbook for learning methods. It is also to some extent out of date
Rating: 4 / 5
the authors bestow an epidemiologic approach to the study of genetic and environmental factors in health and disease. The book is comprehensive and lucid — and captivatingly simple. I find myself going back to sections of the back even years after having read it the first time. One suggestion: the section on linkage analysis is, in my view, not simple to read and digest as the rest of the book. If you look for texts on linkage, other choices may serve you best. For everything else (on the epidemiologic approach to gene-environment interactions), I know of no better book. It should be integrated with a review paper or two on more recent techniques (TDT, case-triads, case-only studies) that have been developed after the publication of the book. This book is in my library to stay.
Rating: 4 / 5