Crystallography Made Crystal Clear, Second Edition: A Guide for Users of Macromolecular Models
Crystallography Made Crystal Clear, Second Edition: A Guide for Users of Macromolecular Models Books
Product Description
Macromolecules are the proteins and nucleic acids upon which life depends. Understanding the action of biological macromolecules (giant molecules) requires detailed knowledge of their structures. Most of the more than ten thousand known structures of protein and nucleic acids were obtained by x-ray crystallography, the standard means for determining protein structure. Essentially, proteins are frozen into rigid crystals, which can be stacked up in a repeating pattern–like supermarket displays. The structure of each individual crystal can be determined by the way x-rays are bent when they pass through the composite crystal. Protein structure is essential when investigating protein interactions and plotting drug development.
Crystallography Made Crystal Clear, Second Edition clarifies how scientists learn the structures of the macromolecules. Scientists do not see these molecules directly. Instead, they build models as a means of interpreting data from x-ray diffraction by crystals, or by irradiation by other forms of energy. Users of these models need to know how they are obtained in order to know what they are seeing when they study a develop of a macromolecule. They also need to know how to judge whether conclusions they draw from the molecular models are really supported by the models. This book uses visual and geometric models to help readers know the mathematics that forms the basis of x-ray crystallography.
The field of protein crystallography is growing every day and has been instrumental in learning the molecular principles of biology and in learning new drugs, such as the recent protease inhibitors for AIDS. The field includes the largest percentage of Nobel prizes than any other scientific discipline. Every major university and drug company has a protein crystallography laboratory and this book is an invaluable aid to those wishing to do protein crystallography
or just learn more about how it is really done.
Key Features
* Provides clear, understandable descriptions of principles of X-ray crystallography
* Leads reader through unintimidating and thorough explanations of the underlying mathematics
* Provides abundant illustrations, including diagrams, charts, photographs, and color stereo
* images
* Clarifies how to read crystallography papers in research journals
* Includes brief descriptions of other diffraction methods (neutron, electron, Laue) and the kinds
* of structural in rank they can provide
* Introduces other methods of macromolecular structure determination (NMR spectroscopy and
* homology modeling), and provides guidance in judging the quality of these models
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The delivery was prompt and in the item was in an brilliant shape up
Rating: 5 / 5
Crystallography Made Crystal Clear does clearly clarify the principles of X-ray Crystallography. I used this book for a graduate class in introductory x-ray crystallography when I deemed that the assigned book for the class, Principles of Protein X-Ray Crystallography, unhelpful.
Crystallography Made Crystal Clear presents the theory behind crystallography in the most undemanding way possible. Whenever possible, concepts are clarified in words and by examples instead of with equations. This elimates derivations that are not necessary to know key concepts.
Although explanations in the book are clear, they are often too brief. The book also does not have any do problems, which is a major drawback. If you are taking a crystallography class, I would take a look at this book but focus more heavily on the address notes and problems from class. Honestly, I haven’t found a really excellent crystallography book, but this one at least is not too confusing.
Rating: 3 / 5
The book came in very excellent shape up. The delivery took a few more days than I was expecting but it came in enough time for it to be helpful. Overall it was a excellent buy for a excellent price and i’d buy from the seller again.
Rating: 5 / 5
This book is a excellent one. Clarifies every aspect I everlastingly want to know about crystallography. In my first class of biochemistry I learn that I really like the macromolecular models, but my biochemistry book doesn’t content much in rank about this subjet. When I learn this book I bought it, and read it, and I must to say that this book clarify every aspect of the administer of make a molecular develop.
After read this book I thought about to become a crystallographer.
Rating: 5 / 5
The perfect bridge between simple introductions and more complete books, both trying to know for the non-crystallographer. Very clear explanations -crystal clear- and real examples from real papers. Just what I sought after to know. No more no less.
Rating: 5 / 5