Cluster Randomised Trials
Cluster Randomised Trials Books
Product Description
Cluster Randomised Trials discusses the design, conduct, and analysis of health trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomization, with unique attention given to evaluating the effects of interventions hostile to infectious diseases.
Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. The authors also bestow an array of design issues in cluster randomised trials (CRTs), including strategies for minimizing contamination effects, the use of stratification and top secret randomisation to improve balance between treatment arms, unique methods for sample size calculation, and alternatives to the simplest two-arm CRT. After covering analytical methods for CRTs, such as regression methods, the authors examine ethical issues, trial monitoring, interim analyses, reporting, and interpretation.
Although the book mainly focuses on medical and broadcast health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform broadcast policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.
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This is a “must have” book for any busy clinician participating in clinical trials. The authors have done an admirable job of maintenance the math to a minimum even as still including enough to provide statistical heft.
With large clinical trials apt ubiquitous in modern evidence-based medicine, understanding the in rank generated by statistical analysis of the data generated by these studies will be essential for the practitioner as well as the hardened researcher.
Rating: 5 / 5