Clinical Trials: A Methodologic Perspective Second Edition
Clinical Trials: A Methodologic Perspective Second Edition Books
Product Description
Learn rigorous statistical methods to make sure valid clinical trials
This Second Edition of the critically hailed Clinical Trials builds on the text’s reputation as a undemanding and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete administer of plotting the experiment, assembling a study cohort, assessing data, and reporting consequences. Throughout the administer, the author alerts readers to problems that may arise during the course of the trial and provides commonsense solutions.
The author bases the revisions and updates on his own classroom experience, as well as feedback from students, instructors, and medical and statistical professionals caught up in clinical trials. The Second Edition greatly expands its coverage, ranging from statistical principles to controversial topics, including alternative medicine and ethics. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First Edition will learn absolutely new chapters, including:
* Contexts for clinical trials
* Statistical perspectives
* Translational clinical trials
* Dose-finding and dose-ranging designs
Each chapter is accompanied by a summary to reinforce the key points. Revised discussion questions stimulate critical thought and help readers know how they can apply their newfound knowledge, and updated references are provided to direct readers to the most recent literature.
This text distinguishes itself with its accessible and broad coverage of statistical design methods–the crucial building blocks of clinical trials and medical research. Readers learn to conduct clinical trials that yield valid qualitative consequences backed by rigorous statistical methods.
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This is an brilliant book. It outlines the vital issues of clinical trials well. It is understandable and thorough. A must for anyone who is interested in really doing trials. Not a excellent book for a brief, superficial overview.
Rating: 5 / 5
Covers many aspects of trials (particularly facets of design and analysis)not yet covered by other books, eg randomisation with minimisation, and meta-analysis of trial consequences. Readable, applicable, matter-of-fact, excellent references, well structured.
Rating: 5 / 5
The quantity of knowledge and the scope of this book are the exact need for the first contact with clinical trials. Yet, it is not a simple or superficial text. Instead, it not only will guide the reader through the basics of trials (and there is so much that is not basic in it) but the author points the reader to hundreds of papers and books that are landmarks. I regard this book itself as one of these landmarks!
Rating: 5 / 5
This book is very unique. Basic statistical concepts are clearly presented but only those concepts that are vital in clinical trials. The author presents all the issues with clinical trials including ethical issues with some historical perspective. Principles of randomization and statistical design are clearly presented. It offers discussion of Bayesian techniques and meta-analyses, thwart-over designs and group sequential methods (interim analyses). For statisticians doing clinical research like myself, this is a valuable reference source.
Rating: 5 / 5