Biocatalysis in the Pharmaceutical and Biotechnology Industries
Biocatalysis in the Pharmaceutical and Biotechnology Industries Books
Product Description
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react even as prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to yield fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications.
Written by internationally recognized scientists in biocatalysis, the authors question the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cold-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.
Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for vehicle immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the matter-of-fact advantages and methodologies for using biocatalysts to develop and yield chiral pharmaceuticals and fine chemicals.
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