A Means to an End: The Biological Basis of Aging and Death
A Means to an End: The Biological Basis of Aging and Death Books
Product Description
Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its bestow limits? Because growing ancient has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are sincerely challenging the assumption that human lifespans are beyond our control.
With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence starts at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer’s disease, and the insights gained through studying human genetic disorders–such as Werner’s syndrome–that mimic the symptoms of aging. Clark also clarifies how reduction in caloric intake may really help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidantsfound in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.
This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to question in the next century.
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Dr. Clark has written so perfectly on a topic which is not everlastingly clearly clarified. In caring for elderly patients and looking at our own health decisions, we can truly benefit from his efforts to give us his years of molecular biology experience in a well-calculated format. Thank you Dr. Clark.
Ellen M. O’Donohue RN BSN Kelpgull@aol.com
Rating: 5 / 5
Simple to read book. After lengthy introduction author concentrates on the research about genes that suppress the cell senescence and control. Discussion about cancer cells where cell division is not checked.
Final chapters discusses the effects of oxidants, obesity, low calorie diet or similar things where eventually a claim comes that beside the gene control everything else does not quantity more than %15 in total effect.
So unless we control the genes we will soon or later die.
Rating: 4 / 5
Professor Clark has written a book that is detailed and right, and at the same time accessible to people untrained in molecular biology. If you are interested in increasing both the quality and the part of your life, read this book.
Rating: 5 / 5
This book embraces a rational and well clarified journey in the field of aging. Here I read for the first time strong statements about the programmed nature death, that is bestow since fertilization. We learn the basic experiments that support Haldane theory about sex and aging and we appreaciate the beatiful connection between replicative senescence and species-specifc mortality. The book is clear and well readible and I strongly urge it to science and non-science crowd.
Rating: 5 / 5
This is a very clearly written, basic book on aging research that is up-to-date. It covers the history of aging research, with particular emphasis on Hayflick’s demonstraction of replicative senesence, and gives a fascinating speculation regarding the origin of the aging administer in eukaryotic cells as a consequence of sex. Despite this, I really reckon this is a non-technical book, as he takes time to clarify even the most basic of basics, like how nucleotides make up DNA.
Rating: 5 / 5